孙乐乐，男，副教授，硕士生导师
Tel：021-6613 2912
E-mail：sunlele@shu.edu.cn
个人简介：
孙乐乐，籍贯河南焦作，副教授，硕士生导师。2013年本科毕业于河南师范老员工命科学公司，2018年博士毕业于中国科公司上海应用物理研究所，2018年-2021年在苏州大学功能纳米与软物质研究院从事博士后研究。2021年7月到威尼斯游戏的网址(中国)集团有限公司官网工作，任副教授。主要研究领域聚焦于功能核酸材料的生物医学应用，近年来围绕功能DNA及框架核酸结构的免疫调节治疗，做出了系列创新工作，已在Journal of the American Chemical Society、Angewandte Chemie-International Edition、Advanced Materials、Nano Letters、Chemical Science等国际知名期刊发表一作或通讯论文10余篇。受邀担任JACS-Au, ACS Nano, AFM，ACS AMI等国际知名期刊审稿人。
研究方向/领域
² DNA纳米技术
² 免疫工程
近年主持/参与的研究项目
1. 博士后面上项目（2019-2021）主持
2. 国家自然科学基金青年项目（2020-2022），23万，主持
3. 国家自然科学基金面上项目（2023-2026），54万，主持
4. 国家科技部重点研发计划青年科学家项目(2022-2024)，100万，课题负责人
5. 集团高层次人才引进启动资金，75万（2021-2023）
近期代表性研究成果
Fengyun Shen, Zijian Xiong, Yumin Wu, Rui Peng, Yue Wang, Lele Sun*, Chunhai Fan, and Zhuang Liu*. Precise Epitope Organization with Self-adjuvant Framework Nucleic Acid for Efficient COVID-19 Peptide Vaccine Construction. Angewandte Chemie-International Edition, 2023, https://doi.org/10.1002/anie.202301147. (IF 16.823)
Lele Sun* and Zhuang Liu*. Precise regulation of intermembrane spacing with DNA nanojunctions for enhanced T-cell receptor triggering. Science China-Chemistry, 2023, https://doi.org/10.1007/s11426-023-1571-9. (IF 10.152)
Zijian Xiong, Lele Sun*, He Yang, Zhisheng Xiao, Zheng Deng, Quguang Li, Chenya Wang, Fengyun Shen, and Zhuang Liu*. Ni-Alginate Hydrogel Microspheres with Sustained Interleukin 2 Release to Boost Cytokine-Based Cancer Immunotherapy. Advanced Functional Materials, 2022, 2211423. (IF 19.924)
Yanfei Qu, Fengyun Shen, Ziyi Zhang, Qi Wang, Hao Huang, Yufei Xu, Qian Li, Xiaoli Zhu*, and Lele Sun*. Applications of Functional DNA Materials in Immunomodulatory Therapy. ACS Applied Materials & Interfaces, 2022 14 (40), 45079-45095. (IF 10.383)
Shen, Fengyun; Sun, Lele*; Wang, Lihua; Peng, Rui*; Fan, Chunhai; Liu, Zhuang*. Framework Nucleic Acid Immune Adjuvant for Transdermal Delivery Based Chemo-immunotherapy for Malignant Melanoma Treatment. Nano letters, 2022, 22(11), 4509-4518. (IF 12.262)
Sun, Lele; Shen, Fengyun; Xiong, Zijian; Yang, He; Dong, Ziliang; Xiang, Jian; Gu, Qingyang; Ji, Qunsheng; Fan, Chunhai; Liu, Zhuang*. DNA Engineered Lymphocyte-Based Homologous Targeting Artificial Antigen-Presenting Cells for Personalized Cancer Immunotherapy. Journal of the American Chemical Society, 2022, 144 (17), 7634-7645. (IF 16.383)
Sun, Lele; Shen, Fengyun; Tian, Longlong; Tao, Huiquan; Xiong, Zijian; Xu, Jun; Liu Zhuang*, ATP-Responsive Smart Hydrogel Releasing Immune Adjuvant Synchronized with Repeated Chemotherapy or Radiotherapy to Boost Antitumor Immunity. Advanced Materials, 2021, 33(18), 2007910. (IF 32.086)
Sun, LeLe; Shen, Fengyun; Xu, Jun; Han, Xiao; Fan, Chuanhai; Liu Zhuang*, DNA-Edited Ligand Positioning on Red Blood Cells to Enable Optimized T Cell Activation for Adoptive Immunotherapy. Angewandte Chemie-International Edition, 2020, 59(35), 14842-14853. (IF 16.823)
Sun, Lele, Su, Yingying, Wang, Jungang, Xia, Fei, Xu, Ying and Di Li*. DNA nanotweezers for stabilizing and dynamically lighting up a lipid raft on living cell membranes and the activation of T cells. Chemical Science, 2020, 11(6), 1581-1586. (IF 9.969)
Sun, Lele; Gao, Yanjing; Wang, Yaoguang; Wei, Qin; Shi, Jiye; Chen, Nan; Li, Di* and Fan, Chunhai, Guiding protein delivery into live cells using DNA programmed membrane fusion. Chemical Science, 2018, 9 (27), 5967-5975. (IF 9.969)
Sun, Lele; Gao, Yanjing; Xu, Yan; Chao, Jie; Liu, Huajie; Wang, Lianhui; Li, Di* and Fan, Chunhai, Real-Time Imaging of Single-Molecule Enzyme Cascade Using a DNA Origami Raft. Journal of the American Chemical Society, 2017, 139 (48), 17525-17532. (IF 16.383)
招生专业/方向
² 0710 生物学 >> 细胞生物学